Are you able to leverage the latest modalities?

• If a chronic wound hasn’t healed by 53% in the first 30 days, it has a 9% chance to close.

• There is a compelling case for deploying advanced therapies as soon as possible.

• Barriers:

  • Biofilm

  • Diagnostics

  • Access to Care

• Grafting therapies are widely used for:

  • Building of ECM for the body’s cells to inhabit

  • Growth factor delivery to stimulate proliferation of those cells

• Energy-based therapies stimulate tissue regeneration

  • Electromagnetic frequencies in the sonic & ultrasonic spectra can induce growth factor production and lead to angiogenesis.

4 characteristics for rapidly building tissue:

• Does the graft have natural topography for cells to grow into?

• Does it match the skin’s complex chemical profile?

• How does it influence growth factors in the wound?

• Will the host recognize graft structure as homologous to speed integration?

Dermal Templates

• These reduce the time spent by cells building Extracellular Matrix.

• The ideal dermal template attracts proliferating cells.

• The more closely matched chemically & structurally to human dermis, the more rapidly integration occurs.

When considering grafts rich with growth factors, what’s important?

• Handling is important. Will it ball up? Can it handle being stitched?

• Does the production process maintain quantity & concentration of growth factors?

• If cryopreserved:

  • How much time needs to be dedicated to logistics?

  • If appointment is missed, does the graft go to waste?

• If dried:

  • Are any structural or chemical components removed or damaged during procurement, production, or drying processes?

Too many patients live in fear of painful debridements.

• What if something could achieve biofilm disruption & stimulation of cell proliferation, without the need for debridement?

  Non-contact Low Frequency Ultrasound (NLFU) has been shown to reduce bioburden & inflammatory cytokines, while stimulating release of growth factors like VEGF to aid in neovascularization.

Providers at the forefront of innovation are re-evaluating wound progress every 30 days.

• Is treatment achieving maximal effect? ​

• Should diagnostics be revisited?

• What can we add, change, or enhance?